Yan Zhao's Publications


Yan Zhao's departmental profile: https://www.chem.iastate.edu/people/yan-zhao

Research Interests: https://www.chem.iastate.edu/yan-zhao-research-interests

Recent group photos: https://www.chem.iastate.edu/zhao-group


143. Foroogh Bahrami and Yan Zhao* “Carbonic Anhydrase Mimic with Rationally Designed Active Site for Fine-Tuned Catalytic Activity and Selectivity in Ester Hydrolysis,” Catal. Sci. Technol. 2023, 13, in press. https://doi.org/10.1039/D3CY00704A

2023_CatalST_MINP CA mimic

142. Ishani Bose and Yan Zhao* “Supramolecular Regulation of Catalytic Activity in Molecularly Responsive Catalysts,” J. Org. Chem. 2023, 88, in press. https://doi.org/10.1021/acs.joc.3c00710

2023_JOC_tunable catalysis

141. Mansi Sharma, Ishani Bose, and Yan Zhao* “Acid-Functionalized Artificial Enzymes with Tunable Selectivity for Vinyl Ether Hydrolysis,” J. Org. Chem. 2023, 88, 11263–11267. https://doi.org/10.1021/acs.joc.3c00522

2023_JOC_vinyl ether hydrolysis

140. Ishani Bose, Foroogh Bahrami, and Yan Zhao* “Artificial Esterase for Cooperative Catalysis of Ester Hydrolysis at pH 7,” Mater. Today Chem. 2023, 30, 101576. https://doi.org/10.1016/j.mtchem.2023.101576

2023_MaterToday_ester hydrolysis

139. Milad Zangiabadi, Avijit Ghosh, and Yan Zhao,* “Nanoparticle Scanners for the Identification of Key Sequences Involved in the Assembly and Disassembly of β-Amyloid Peptides,” ACS Nano 2023, 17, 4764–4774. https://doi.org/10.1021/acsnano.2c11186


138. MD Arifuzzaman and Yan Zhao* “Selective Hydrolysis of Nonactivated Aryl Esters at pH 7 through Cooperative Catalysis,” J. Org. Chem. 2023, 88, 3282-3287. https://doi.org/10.1021/acs.joc.2c02570

2023_JOC_aryl ester hydrolysis


137. Yan Zhao,* “Molecularly Imprinted Materials for Glycan Recognition and Processing,” Invited Perspective, J. Mater. Chem. B. 2022, 10, 6607–6617. https://doi.org/10.1039/D2TB00164K


136. Milad Zangiabadi and Yan Zhao,* “Synergistic Hydrolysis of Cellulose by a Blend of Cellulase-Mimicking Polymeric Nanoparticle Catalysts,” J. Am. Chem. Soc. 2022144, 17110–17119. https://doi.org/10.1021/jacs.2c06848 (A JACS Spotlight Article, see https://pubs.acs.org/doi/full/10.1021/jacs.2c09779)

2022_JACS_synthetic cellulase blend

135. Milad Zangiabadi and Yan Zhao,* “Controlling Enzyme Reaction Paths by Substrate Protection and Deprotection,” Chem. Commun. 2022, 58, 9770–9773. https://doi.org/10.1039/D2CC03239B

2022_ChemComm_glycan protection

134. MD Arifuzzaman, Ishani Bose, Foroogh Bahrami, and Yan Zhao,* “Imprinted Polymeric Nanoparticles as Artificial Enzymes for Ester Hydrolysis at Room Temperature and pH 7,” Chem Catal. 2022, 2, 2049–2065. (These authors contributed equally). https://doi.org/10.1016/j.checat.2022.06.007 (highlighted in Chem. Catal.https://www.sciencedirect.com/science/article/abs/pii/S2667109322003955)


133. Kaiqian Chen, Milad Zangiabadi, and Yan Zhao* “Oxidative Cleavage of Glycosidic Bonds by Synthetic Mimics of Lytic Polysaccharide Monooxygenases (LPMOs),” Org. Lett. 2022, 24, 3426–3430. https://doi.org/10.1021/acs.orglett.2c01312

2022_OL_oxidative cleavage

132. Kaiqian Chen and Yan Zhao* “Dynamic Tuning in Synthetic Glycosidase for Selective Hydrolysis of Alkyl and Aryl Glycosides,” J. Org. Chem. 2022, 87, 4195–4203. https://doi.org/10.1021/acs.joc.1c03029


131. Ishani Bose and Yan Zhao* “Site-Selective Catalytic Epoxidation of Alkene with Tunable, Atomic Precision by Molecularly Imprinted Artificial Epoxidases,” ACS Catal. 2022, 12, 3444–3451. https://doi.org/10.1021/acscatal.2c00253


130. Yan Zhao,* “Artificial Enzymes Created Through Molecular Imprinting of Cross-Linked Micelles,” In Supramolecular Catalysis: New Directions and Developments; Piet W.N.M. van Leeuwen, Matthieu Raynal, Eds.; Wiley-VCH: Weinheim, 2022; Chapter 15. https://onlinelibrary.wiley.com/doi/10.1002/9783527832033.ch15

2022_Supramolecular Catalysis Book

129. Xiaowei Li and Yan Zhao,* “Environmental Modulation of Chiral Prolinamide Catalysts for Stereodivergent Conjugate Addition,” J. Catal. 2022, 406, 126–133.  https://doi.org/10.1016/j.jcat.2022.01.003


128. Kaiqian Chen and Yan Zhao,* “Molecular Recognition of Enzymes and Modulation of Enzymatic Activity by Nanoparticle Conformational Sensors,” Chem. Commun. 2022, 58, 1732–1735. https://doi.org/10.1039/D1CC05699A

2022_ChemComm_enzyme modulation


127. Yan Zhao,* “Substrate Protection in Controlled Enzymatic Transformation of Peptides and Proteins,” Invited Concept Paper, ChemBioChem 202122, 2680–2687. http://dx.doi.org/10.1002/cbic.202100217


126. Ishani Bose and Yan Zhao* “Tandem Aldol Reaction from Acetal Mixtures by an Artificial Enzyme with Site-Isolated Acid and Base Functionality,” ACS Appl. Polym. Mater. 2021, 3, 2776–2784. https://doi.org/10.1021/acsapm.1c00299

2021_ACSAPM_tendem cross aldol

125. Ishani Bose and Yan Zhao* “Selective Hydrolysis of Aryl Esters under Acidic and Neutral Conditions by a Synthetic Aspartic Protease Mimic,” ACS Catal. 2021, 11, 3938–3942. https://doi.org/10.1021/acscatal.1c00371

2021_ACSCatal_Aspartic Protease Mimic

124. Xiaowei Li, Milad Zangiabadi, and Yan Zhao* “Molecularly Imprinted Synthetic Glucosidase for the Hydrolysis of Cellulose in Aqueous and Nonaqueous Solutions,” J. Am. Chem. Soc. 2021143, 5172–5181. https://doi.org/10.1021/jacs.1c01352


123. Xiaowei Li, Kaiqian Chen, and Yan Zhao* “Sequence-Selective Protection of Peptides from Proteolysis,” Angew. Chem. Int. Ed. 202160, 11092–11097. https://doi.org/10.1002/anie.202102148

2021_Angew_Peptide protection

122. Xiaowei Li, Tania M. Palhano Zanela, Eric S. Underbakke, and Yan Zhao* “Controlling Kinase Activities by Selective Protection of Peptide Substrates,” J. Am. Chem. Soc. 2021143, 639–643. https://doi.org/10.1021/jacs.0c11566


121. Ishani Bose, Shixin Fa, and Yan Zhao* “A Tunable Artificial Enzyme–Cofactor Complex for Selective Hydrolysis of Acetals,” J. Org. Chem. 2021, 86, 1701–1711. https://doi.org/10.1021/acs.joc.0c02519


120. Xiaowei Li and Yan Zhao,* “Synthetic Glycosidase for the Precise Hydrolysis of Oligosaccharides and Polysaccharides,” Chem. Sci. 2021, 12, 374–383. https://doi.org/10.1039/D0SC05338D


119. Likun Duan and Yan Zhao,* “Molecularly Imprinted Micelles for Fluorescent Sensing of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs),” React. Funct. Polym. 2021, 156, 104759. https://doi.org/10.1016/j.reactfunctpolym.2020.104759



118. Ishani Bose and Yan Zhao,* “pH-Controlled Nanoparticle Catalysts for Highly Selective Tandem Henry Reaction from Mixtures,” ACS Catal. 2020, 10, 13973–13977. https://doi.org/10.1021/acscatal.0c03468


117. Xiaowei Li and Yan Zhao,* “Synthetic Glycosidase Distinguishing Glycan and Glycosidic Linkage in Its Catalytic Hydrolysis,” ACS Catal. 2020, 10, 13800–13808. https://doi.org/10.1021/acscatal.0c04038


116. Likun Duan, Milad Zangiabadi, and Yan Zhao,* “Synthetic Lectins for Selective Binding of Glycoproteins in Water,” Chem. Commun. 2020, 56, 10199–10202. https://doi.org/10.1039/D0CC02892D


115. Milad Zangiabadi and Yan Zhao,* “Molecularly Imprinted Polymeric Receptors with Interfacial Hydrogen Bonds for Peptide Recognition in Water,” ACS Appl. Polym. Mater. 2020, 2, 3171–3180. https://doi.org/10.1021/acsapm.0c00354


114. Milad Zangiabadi and Yan Zhao,* “Selective Binding of Complex Glycans and Glycoproteins in Water by Molecularly Imprinted Nanoparticles,” Nano Lett. 2020, 20, 5106–5110. http://dx.doi.org/10.1021/acs.nanolett.0c01305


113. Likun Duan and Yan Zhao,* “Zwitterionic Molecularly Imprinted Cross-Linked Micelles for Alkaloid Recognition in Water,” Chem. Asian. J. 2020, 15, 1035–1038. http://dx.doi.org/10.1002/asia.201901783

2020_CAJ_dopamine MINP


112. Likun Duan and Yan Zhao,* “Zwitterionic Molecularly Imprinted Cross-Linked Micelles for Alkaloid Recognition in Water,” J. Org. Chem. 2019, 84, 13457–13464. http://dx.doi.org/10.1021/acs.joc.9b01629

2019_JOC_alkaloid MINP

111. Kaiqian Chen and Yan Zhao,* “Effects of Nano-Confinement and Conformational Mobility on Molecular Imprinting of Cross-Linked Micelles,” Org. Biomol. Chem. 2019, 17, 8611–8617. http://dx.doi.org/10.1039/C9OB01440C


110. Xiaowei Li and Yan Zhao,* “Chiral Gating for Size-Selective Asymmetric Catalysis in Water,” J. Am. Chem. Soc. 2019141, 13749–13752. https://doi.org/10.1021/jacs.9b06619 (Featured on JACS cover and highlighted on ChemistryViews, see https://www.chemistryviews.org/details/news/11175789/Pre-Shaped_Nanopart...)


109. Shixin Fa and Yan Zhao,* “A General Method for Peptide Recognition in Water through Bioinspired Complementarity,” Chem. Mater. 201931, 4889–4896. https://doi.org/10.1021/acs.chemmater.9b01613

2019_General Method for Peptide Binding

108. Lan Hu, MD Arifuzzaman, and Yan Zhao,* “Controlling Product Inhibition through Substrate-Specific Active Sites in Nanoparticle-Based Phosphodiesterase and Esterase,” ACS Catal. 2019, 9, 5019–5024. http://dx.doi.org/10.1021/acscatal.9b00630

2019 Product Inhibition

107. Roshan W. Gunasekara and Yan Zhao,* “Binding and Protection of Glycosphingolipids by Synthetic Nanoparticles,” Chem. Commun201955, 4773–4776. http://dx.doi.org/10.1039/C9CC01694E

2019_Glycosphingo lipid

106. Lan Hu and Yan Zhao,* “A Bait-and-Switch Method in the Construction of Artificial Esterases for Substrate-Selective Hydrolysis,” Chem. –Eur. J. 2019, 25, 7702–7710. (Hot Paper). https://doi.org/10.1002/chem.201900560

2019_Bait and Switch

105. Shixin Fa and Yan Zhao,* “Synthetic Nanoparticles to Catalyze Selective Hydrolysis of Bacterial Autoinducers in Quorum Sensing,” Bioorg. Med. Chem. Lett. 2019, 29, 978–981. https://doi.org/10.1016/j.bmcl.2019.02.016

2019_AHL Hydrolysis

104. Chuanqi Li, Jing Zhang, Shiyong Zhang,* and Yan Zhao, “Efficient Light Harvesting Systems with Tunable Emission through Controlled Precipitation in Confined Nanospace,” Angew. Chem. Int. Ed. 2019, 58, 1643–1647. https://doi.org/10.1002/anie.201812146



103. Shize Zhang and Yan Zhao,* “Tuning Surface-Cross-Linking of Molecularly Imprinted Cross-Linked Micelles for Molecular Recognition in Water,” J. Mol. Recognit. 2018, 31, e2769. http://dx.doi.org/10.1002/jmr.2769


102. MD Arifuzzaman and Yan Zhao,* “Artificial Zinc Enzymes with Fine-Tuned Catalytic Active Sites for Highly Selective Hydrolysis of Activated Esters,” ACS Catal. 2018, 8, 8151–8161. http://dx.doi.org/10.1021/acscatal.8b02292

2018_Zinc-Enzyme mimic

101. Lan Hu and Yan Zhao,* “Molecularly Imprinted Artificial Enzymes with Highly Specific Active Sites and Precisely Installed Catalytic Groups,” Org. Biomol. Chem. 2018, 16, 5580–5584. http://dx.doi.org/10.1039/C8OB01584H


100. MD Arifuzzaman, Wei Zhao, and Yan Zhao,* “Surface Ligands in the Imprinting and Binding of Molecularly Imprinted Cross-Linked Micelles,” Supramol. Chem. 2018, 30, 929–939. http://dx.doi.org/10.1080/10610278.2018.1489540

2018_Suface Ligands

99. Yan Zhao,* “Sequence-Specific Recognition of Peptides in Aqueous Solution—A Supramolecular Approach through Micellar Imprinting,” Chem. –Eur. J. 2018, 24, Invited Concept Paper, 14001–14009. https://doi.org/10.1002/chem.201801401

2018_Peptide Concept

98. Xiaoyu Xing and Yan Zhao,* “Intramolecularly Enhanced Molecular Tweezers with Unusually Strong Binding for Aromatic Guests in Unfavorable Solvents,” Org. Biomol. Chem. 2018, 16, 3885–3888. http://dx.doi.org/10.1039/C8OB00786A

2018_Intramolecular Enhancement

97. Xiaoyu Xing and Yan Zhao,* “Fluorescent Nanoparticle Sensors with Tailor-Made Recognition Units and Proximate Fluorescent Reporter Groups,” New J. Chem. 2018, 42, 9377–9380. https://doi.org/10.1039/C8NJ01139G

2018_MINP Acid Sensor

96. Xiaoyu Xing and Yan Zhao,* “Binding-Promoted Chemical Reaction in the Nanospace of a Binding Site: Effects of Environmental Constriction,” Org. Biomol. Chem. 2018, 16, 2855–2859. http://dx.doi.org/10.1039/C8OB00590G

2018_Imine formation

95. Likun Duan and Yan Zhao,* “Selective Binding of Folic Acid and Derivatives by Imprinted Nanoparticle Receptors in Water,” Bioconjugate Chem. 2018, 29, 1438–1445. http://dx.doi.org/10.1021/acs.bioconjchem.8b00121

2018_Folic acid

94. Xiaoyu Xing and Yan Zhao,* “Aromatically Functionalized Pseudo Crown Ethers with Unusual Solvent Response and Enhanced Binding Properties,” Org. Biomol. Chem. 2018, 16, 1627–1631. http://dx.doi.org/10.1039/C8OB00100F

2018_Enhanced Pseudo Crowns

93. Shixin Fa and Yan Zhao,* “Water-Soluble Imprinted Nanoparticles Supramolecularly Coded for Peptides with Hydrophobic and Acidic Side Chains,” Chem. –Eur. J. 2018, 24, 150–158 (Hot Paper). http://dx.doi.org/10.1002/chem.201703760

2017_MINPs for acidic peptides


92. Shixin Fa and Yan Zhao,* “Peptide-Binding Nanoparticle Materials with Tailored Recognition sites for Basic Peptides,” Chem. Mater. 2017, 29, 9284–9291. http://dx.doi.org/10.1021/acs.chemmater.7b03253

2017_ChemMater_Basic Peptide

91. Li-Chen Lee, Xiaoyu Xing, and Yan Zhao,* “Microenvironmental Engineering of Pd Nanoparticle Catalysts for Improved Activity in Hydrogenation of CO2 and Bicarbonate,” ACS Appl. Mater. Interfaces 2017, 9, 38436–38444. http://dx.doi.org/10.1021/acsami.7b10591

2017_CO2 reduction

90. Roshan W. Gunasekara and Yan Zhao,* “Intrinsic Hydrophobicity versus Intraguest Interactions in Hydrophobically Driven Molecular Recognition in Water,” Org. Lett. 2017, 19, 4159–4162. http://dx.doi.org/10.1021/acs.orglett.7b01535


89. Lan Hu and Yan Zhao,* “Molecularly Imprinted Cross-Linked Micelles as Artificial Enzymes for Biomimetic Hydrolysis of Activated Esters,” Helv. Chim. Acta 2017, 100, e1700147. http://dx.doi.org/10.1002/hlca.201700147


88. Joseph K. Awino and Yan Zhao,* “Imprinted Micelles for Chiral Recognition in Water: Shape, Depth, and Number of Recognition Sites,” Org. Biomol. Chem. 2017, 15, 4851–4858. http://dx.doi.org/10.1039/C7OB00764G


87. Joseph K. Awino, Roshan W. Gunasekara, and Yan Zhao,* “Sequence-Selective Binding of Oligopeptides in Water through Hydrophobic Coding,” J. Am. Chem. Soc. 2017, 139, 2188–2191. http://dx.doi.org/10.1021/jacs.6b12949 (A JACS Spotlight Article, see https://pubs.acs.org/doi/full/10.1021/jacs.7b01444)

2017_Peptide-binding MINPs

86. Roshan W. Gunasekara and Yan Zhao,* “A General Method for Selective Recognition of Monosaccharides and Oligosaccharides in Water,” J. Am. Chem. Soc. 2017, 139, 829–835. http://dx.doi.org/10.1021/jacs.6b10773

2017_Oligosaccharide-binding MINPs


85. Joseph K. Awino, Roshan W. Gunasekara, and Yan Zhao,* “Selective Recognition of D-Aldohexoses in Water by Boronic Acid-Functionalized Molecularly Imprinted Cross-Linked Micelles,” J. Am. Chem. Soc. 2016, 138, 9759–9762. http://dx.doi.org/10.1021/jacs.6b04613

2016_Monosaccaride-Binding MINP

84. MD Arifuzzaman and Yan Zhao,* “Water-Soluble Molecularly Imprinted Nanoparticles Receptors with Hydrogen-Bond-Assisted Hydrophobic Binding,” J. Org. Chem. 2016, 81, 7518–7526. http://dx.doi.org/10.1021/acs.joc.6b01191

2016_H-Bonded MINP

83. Yan Zhao,* “Surface-Cross-Linked Micelles as Multifunctionalized Organic Nanoparticles for Controlled Release, Light Harvesting, and Catalysis,” Langmuir 201632, 5703–5713, Invited Feature Article. http://pubs.acs.org/doi/abs/10.1021/acs.langmuir.6b01162


82. Joseph K. Awino, Lan Hu, and Yan Zhao,* “Molecularly Responsive Binding through Co-occupation of Binding Space: A Lock–Key Story,” Org. Lett. 2016, 18, 1650–1653. http://dx.doi.org/10.1021/acs.orglett.6b00527

2016_OL_Cooperative Binding of Two Guests

81. Roshan W. Gunasekara and Yan Zhao,* “Enhancing binding affinity and selectivity through preorganization and cooperative enhancement of the receptor,” Chem. Commun201652, 4345–4348. http://dx.doi.org/10.1039/C5CC10405J

2016_ChemComm_Citrate-Binding CERs

80. Linxing Yao, Xueshu Li, Tong Wang,* and Yan Zhao,* “Design and Synthesis of Cross-Linked Micellar Particles to Assist Microalgae Lipid Recovery from Aqueous Extract,” J. Am. Oil Chem. Soc. 2016, 93, 51–60. http://dx.doi.org/10.1007/s11746-015-2744-y


79. Gina M. Roberts, Shiyong Zhang, Yan Zhao,* L. Keith Woo,* “Improving Reactivity and Selectivity of Aqueous-Based Heck Reactions by the Local Hydrophobicity of Phosphine Ligands,” Tetrahedron 2015, 71, 8263–8270. http://dx.doi.org/10.1016/j.tet.2015.09.010


78. Geetika Chadha, Qing-Zheng Yang,* and Yan Zhao,* “Self-Assembled Light-Harvesting Supercomplexes from Fluorescent Surface-Cross-Linked Micelles,” Chem. Commun. 2015, 51, 12939–12942. http://dx.doi.org/10.1039/C5CC04377H

2015_ChemComm_Dansyl SCM

77. Joseph K. Awino and Yan Zhao,* “Polymeric Nanoparticle Receptors as Mimics of Monoclonal Antibodies for Nonsteroidal Anti-Inflammatory Drugs (NSAIDs),” ACS Biomater. Sci. Eng. 2015, 1, 425–430. http://dx.doi.org/10.1021/acsbiomaterials.5b00042


76. Roshan W. Gunasekara and Yan Zhao,* “Conformationally Switchable Water-Soluble Fluorescent Bischolate Foldamers as Membrane-Curvature Sensors,” Langmuir 201531, 3919–3925. http://dx.doi.org/10.1021/acs.langmuir.5b00379

2015_Langmuir_Membrane Curvature

75. Roshan W. Gunasekara and Yan Zhao,* “Rationally Designed Cooperatively Enhanced Receptors to Magnify Host–Guest Binding in Water,” J. Am. Chem. Soc. 2015, 137, 843–849. http://dx.doi.org/10.1021/ja510823h


74. Li-Chen Lee, Chaoxian Xiao, Wenyu Huang, and Yan Zhao,* “Palladium–Gold Bimetallic Nanoparticle Catalysts by ‘Controlled Release’ from Metal-Loaded Interfacially Cross-Linked Reverse Micelles,” New J. Chem. 2015, 39, 2459–2466. http://dx.doi.org/10.1039/C4NJ01905A


73. Joseph K. Awino and Yan Zhao,* “Water-Soluble Molecularly Imprinted Nanoparticles (MINPs) with Tailored, Functionalized, Modifiable Binding Pockets,” Chem. –Eur. J. 2015, 21, 655–661.  http://dx.doi.org/10.1002/chem.201404919

2015_ChemEJ_Photo MINP

72. Premkumar Rathinam Arivalagan and Yan Zhao,* “Interfacial Catalysis of Aldol Reactions by Prolinamide Surfactants in Reverse Micelles,” Org. Biomol. Chem. 2015, 13, 770–775. http://dx.doi.org/10.1039/C4OB02074J

2015_OBC_MINP Prolinamide


71. Joseph K. Awino and Yan Zhao,* “Molecularly Imprinted Nanoparticles as Tailor-Made Sensors for Small Fluorescent Molecules,” Invited article by Chem. Commun. 2014, 50, 5752–5755. http://dx.doi.org/10.1039/C4CC01516A


70. Li-Chen Lee and Yan Zhao,* “Metalloenzyme-Mimicking Supramolecular Catalyst for Highly Active and Selective Intramolecular Alkyne Carboxylation,” J. Am. Chem. Soc. 2014, 136, 5579–5582. http://dx.doi.org/10.1021/ja501277j


69. Li-Chen Lee and Yan Zhao,* “Room-Temperature Hydroamination of Alkynes Catalyzed by Gold Clusters in Interfacially Cross-Linked Reverse Micelles,” ACS Catal. 2014, 4, 688–691. http://dx.doi.org/10.1021/cs401213c


68. Geetika Chadha and Yan Zhao,* “Environmental Control of Nucleophilic Catalysis in Aqueous Solution,” Chem. Commun. 2014, 50, 2718–2720. http://dx.doi.org/10.1039/C3CC49593K


67. Joseph K. Awino and Yan Zhao,* “Rigidity versus Amphiphilicity in Transmembrane Nanopore Formation by Cholate-Based Macrocycles,” Supramol. Chem. 2014, 26, 302–311. http://dx.doi.org/10.1080/10610278.2013.872784



66. Yan Zhao,* “Cooperatively Enhanced Receptors for Biomimetic Molecular Recognition,” Invited concept article by ChemPhysChem 2013, 14, 3878–3885. http://dx.doi.org/10.1002/cphc.201300744


65. Geetika Chadha and Yan Zhao,* “Histidine-Functionalized Water-Soluble Nanoparticles for Biomimetic Nucleophilic/General-Base Catalysis under Acidic Conditions,” Org. Biomol. Chem. 2013, 11, 6849–6855. http://dx.doi.org/10.1039/C3OB41485J


64. Joseph K. Awino and Yan Zhao,* “Protein-Mimetic, Molecularly Imprinted Nanoparticles for Selective Binding of Bile Salt Derivatives in Water,” J. Am. Chem. Soc. 2013, 135, 12552–12555. http://dx.doi.org/10.1021/ja406089c


63. Yan Zhao,* Hongkwan Cho, Lakmini Widanapathirana, and Shiyong Zhang, “Conformationally Controlled Oligocholate Membrane Transporters: Learning through Water Play,” Invited article by Acc. Chem. Res. 2013, 46, 2763–2772. http://dx.doi.org/10.1021/ar300337f


62. Yu-Zhe Chen, Peng-Zhong Chen, Hui-Qing Peng, Yan Zhao,* Hui-Ying Ding, Li-Zhu Wu, Chen-Ho Tung, Qing-Zheng Yang* “Water-Soluble, Membrane-Permeable Organic Fluorescent Nanoparticles with Large Tunability in Emission Wavelengths and Stokes Shifts,” Chem. Commun. 2013, 49, 5877–5879. http://dx.doi.org/10.1039/C3CC41959B

2013_ChemComm_fluo SCM

61. Xueshu Li and Yan Zhao,* “Oligocholate Foldamer with ‘Prefolded’ Macrocycles for Enhanced Folding in Solution and Surfactant Micelles,” Tetrahedron 2013, 69, 6051–6059. http://dx.doi.org/10.1016/j.tet.2013.05.088


60. Lakmini Widanapathirana and Yan Zhao,* “Tuning Nanopore Formation of Oligocholate Macrocycles by Carboxylic Acid Dimerization in Lipid Membranes,” J. Org. Chem. 2013, 78, 4610–4614. http://dx.doi.org/10.1021/jo400455x

2013_JOC_aromatic Macro

59. Yan Zhao,* “Applications of Metallofoldamers,” In Metallofoldamers: Supramolecular Architectures from Helicates to Biomimetics; Galia Maayan, Markus Albrecht, Eds.; Wiley-VCH: Weinheim, 2013; Chapter 12. http://dx.doi.org/10.1002/9781118517413.ch12

2013_Metallofoldamer Book

58. Geetika Chadha and Yan Zhao,* “Properties of Surface-Crosslinked Micelles Probed by Fluorescence Spectroscopy and Their Catalysis of Phosphate Ester Hydrolysis,” J. Colloid Interface Sci. 2013, 390, 151–157. http://dx.doi.org/10.1016/j.jcis.2012.09.042



57. Tuo Wang, Lakmini Widanapathirana, Yan Zhao,* and Mei Hong,* “Aggregation and Dynamics of Oligocholate Transporters in Phospholipid Bilayers Revealed by Solid-State NMR Spectroscopy,” Langmuir 2012, 28, 17071–17078. http://dx.doi.org/10.1021/la303661p

2012_Langmuir_Solid NMR

56. Xueshu Li and Yan Zhao,* “Tunable Fusion and Aggregation of Liposomes Triggered by Multifunctional Surface Cross-Linked Micelles,” Bioconjugate Chem. 2012, 23, 1721–1725. http://dx.doi.org/10.1021/bc300082b


55. Shiyong Zhang and Yan Zhao,* “Artificial Metalloenzymes via Encapsulation of Hydrophobic Transition-Metal Catalysts in Surface Cross-Linked Micelles,” Chem. Commun. 2012, 48, 9998–10000. http://dx.doi.org/10.1039/C2CC33012A

2012_ChemComm_Catal SCM

54. Lakmini Widanapathirana, Xueshu Li, and Yan Zhao,* “Hydrogen Bond-Assisted Macrocylic Oligocholate Transporters in Lipid Membranes,” Org. Biomol. Chem. 2012, 10, 5077–5083. http://dx.doi.org/10.1039/C2OB25301A


53. Li-Chen Lee and Yan Zhao,* “Interfacially Cross-Linked Reverse Micelles as Soluble Support for Palladium Nanoparticle Catalysts,” Helv. Chim. Acta 2012, 95, 863–871. http://dx.doi.org/10.1002/hlca.201100451


52. Lakmini Widanapathirana and Yan Zhao,* “Effects of Amphiphile Topology on the Aggregation of Oligocholates in Lipid Membranes: Macrocyclic versus Linear Amphiphiles,” Langmuir 2012, 28, 8165–8173. http://dx.doi.org/10.1021/la301090t

2012_Langmuir_Aggregation in membrane

50. Lakmini Widanapathirana and Yan Zhao,* “Aromatically Functionalized Cyclic Tricholate Macrocycles: Aggregation, Transmembrane Pore Formation, Flexibility, and Cooperativity,” J. Org. Chem. 2012, 77, 4679–4687. http://dx.doi.org/10.1021/jo3004056

2012_JOC_aromatic membrane

49. Xueshu Li and Yan Zhao,* “Protection/Deprotection of Surface Activity and Its Applications in the Controlled Release of Liposomal Contents,” Langmuir 2012, 28, 4152–4159. http://dx.doi.org/10.1021/la2050702

2012_Langmuir_Controlled release

48. Hui-Qing Peng, Yu-Zhe Chen, Yan Zhao, Qing-Zheng Yang,* Li-Zhu Wu, Chen-Ho Tung, Li-Ping Zhang, Qing-Xiao Tong,* “Artificial Light-Harvesting System Based on Multifunctional Surface Cross-Linked Micelles,” Angew. Chem. Int. Ed. 2012, 51, 2088–2092. http://dx.doi.org/10.1002/anie.201107723


47. Shiyong Zhang and Yan Zhao,* “Template Synthesis of Subnanometer Gold Clusters in Interfacially Cross-Linked Reverse Micelles Mediated by Confined Counterions,” Langmuir 2012, 28, 3606–3613. http://dx.doi.org/10.1021/la204694c

2012_Langmuir_Au ICRM

46. Li-Chen Lee and Yan Zhao,* “Size-Selective Phase-Transfer Catalysis with Interfacially Cross-Linked Reverse Micelles,” Org. Lett. 2012, 14, 784–787. http://dx.doi.org/10.1021/ol203319w

2012_OL_phase transfer

45. Shiyong Zhang and Yan Zhao,* “Effects of Micelle Properties on the Conformation of Oligocholates and Importance of Rigidity of Foldamers,” J. Org. Chem. 2012, 77, 556–562. http://dx.doi.org/10.1021/jo202156d

2012_JOC_folding in micelle

44. Shiyong Zhang and Yan Zhao,* “Flexible Oligocholate Foldamers as Membrane Transporters and Their Guest-Dependent Transport Mechanism,” Org. Biomol. Chem. 2012, 10, 260–266. http://dx.doi.org/10.1039/C1OB06364B



43. Shiyong Zhang and Yan Zhao,* “Oligocholate Foldamers as Carriers for Hydrophilic Molecules across Lipid Bilayers,” Chem. –Eur. J. 2011, 17, 12444–12451. http://dx.doi.org/10.1002/chem.201101510


42. Hongkwan Cho and Yan Zhao,* “Cholate-Derived Amphiphilic Molecular Baskets as Glucose Transporters across Lipid Membranes,” Chem. Commun. 2011, 47, 8970–8972. http://dx.doi.org/10.1039/C1CC00092F


41. Zhenqi Zhong, Xueshu Li, and Yan Zhao,* “Enhancing Binding Affinity by the Cooperativity between Host Conformation and Host–Guest Interactions,” J. Am. Chem. Soc. 2011, 133, 8862–8865. http://dx.doi.org/10.1021/ja203117g


40. Hongkwan Cho and Yan Zhao,* “Translocation of Hydrophilic Molecules across Lipid Bilayers by Salt-Bridged Oligocholates,” Langmuir 2011, 27, 4936–4944. http://dx.doi.org/10.1021/la2005166


39. Shiyong Zhang and Yan Zhao,* “Facile Preparation of Organic Nanoparticles by Interfacial Crosslinking of Reversed Micelles and Template Synthesis of Subnanometer Au-Pt Nanoparticles,” ACS Nano 2011, 5, 2637–2646. http://dx.doi.org/10.1021/nn102666k


38. Shiyong Zhang and Yan Zhao,* “Controlled Release from Cleavable Polymerized Liposomes upon Redox and pH Stimulation,” Bioconjugate Chem. 2011, 22, 523–528. http://dx.doi.org/10.1021/bc1003197


37. Hongkwan Cho, Lakmini Widanapathirana, and Yan Zhao,* “Water-Templated Transmembrane Nanopores from Shape-Persistent Oligocholate Macrocycles,” J. Am. Chem. Soc. 2011, 133, 141–147. http://dx.doi.org/10.1021/ja109036z


36. Jing Wu, Xingang Pan, and Yan Zhao,* “Time-Dependent Shrinkage of Polymeric Micelles of Amphiphilic Block Copolymers Containing Semirigid Oligocholate Hydrophobes,” J. Colloid Interface Sci. 2011, 353, 420–425. http://dx.doi.org/10.1016/j.jcis.2010.09.071



35. Shiyong Zhang and Yan Zhao,* “Rapid Release of Entrapped Contents from Multi-Functionalizable, Surface Crosslinked Micelles upon Different Stimulation,” J. Am. Chem. Soc. 2010, 132, 10642–10644. http://dx.doi.org/10.1021/ja103391k


34. Hongkwan Cho and Yan Zhao,* “Environmental Effects Dominate the Folding of Oligocholates in Solution, Surfactant Micelles, and Lipid Membranes,” J. Am. Chem. Soc. 2010, 132, 9890–9899. http://dx.doi.org/10.1021/ja103694p


33. Shiyong Zhang and Yan Zhao,* “Facile Synthesis of Multivalent Water-Soluble Organic Nanoparticles via ‘Surface-Clicking’ of Alkynylated Surfactant Micelles,” Macromolecules 2010, 43, 4020–4022. http://dx.doi.org/10.1021/ma100497k



32. Yan Zhao,* “Spacer-Dependant Folding and Aggregation of Oligocholates in SDS Micelles,” J. Org. Chem. 2009, 74, 7470–7480. http://dx.doi.org/10.1021/jo901651h


31. Hongkwan Cho, Zhenqi Zhong, and Yan Zhao,* “A DMAP-Functionalized Oligocholate Foldamer for Solvent-Responsive Catalysis,” Tetrahedron 2009, 65, 7311–7316. http://dx.doi.org/10.1016/j.tet.2009.01.018


30. Yan Zhao,* “Conformation of Oligocholate Foldamers with 4-Aminobutyroyl Spacers,” J. Org. Chem. 2009, 74, 834–843. http://dx.doi.org/10.1021/jo802201b

2009_JOC_flexible oligocholate

29. Xingang Pan and Yan Zhao,* “Efficient Construction of Oligocholate Foldamers via Click Chemistry and Their Tolerance of Structural Heterogeneity,” Org. Lett. 2009, 11, 69–72. http://dx.doi.org/10.1021/ol802364c



28. Zhenqi Zhong and Yan Zhao,* “Controlling the Conformation of Oligocholate Foldamers by Surfactant Micelles,” J. Org. Chem. 2008, 73, 5498–5505. http://dx.doi.org/10.1021/jo800724j



27. Eui-Hyun Ryu, HongKwan Cho, and Yan Zhao,* “Catalyzing Methanolysis of Alkyl Halides in the Interior of an Amphiphilic Molecular Basket,” Org. Lett. 2007, 9, 5147–5150. http://dx.doi.org/10.1021/ol701883u

2007_OL_nano reactor

26. Zhenqi Zhong and Yan Zhao,* “Cholate-Glutamic Acid Hybrid Foldamer and Its Fluorescent Detection of Zn2+,” Org. Lett. 2007, 9, 2891–2894. http://dx.doi.org/10.1021/ol071130g

2007_OL_zinc sensor

25. Yan Zhao,* “Facial Amphiphiles in Molecular Recognition: From Unusual Aggregates to Solvophobically Driven Foldamers,” Curr. Opin. Colloid Interface Sci. 2007, 12, 92–97. http://dx.doi.org/10.1016/j.cocis.2007.05.001


24. Yan Zhao* and Jeffrey S. Moore,* “Foldamers Based on Solvophobic Effects,” In Foldamers: Structure, Properties, and Applications; Stefan Hecht, Ivan Huc, Eds.; Wiley-VCH: Weinheim, 2007. http://dx.doi.org/10.1002/9783527611478.ch3

2007_Foldamer book

23. Yan Zhao,* Zhenqi Zhong, and Eui-Hyun Ryu, “Preferential Solvation in Nanometer-Sized Hydrophilic Cavities and Its Effect on the Folding of Cholate Foldamers,” J. Am. Chem. Soc. 2007, 129, 218–225. http://dx.doi.org/10.1021/ja0671159


22. Yibo Zhou, Eui-Hyun Ryu, Yan Zhao,* and L. Keith Woo,* “Solvent-Responsive Metalloporphyrins: Binding and Catalysis,” Organometallics 2007, 26, 358–364. http://dx.doi.org/10.1021/om060791z



21. Eui-Hyun Ryu and Yan Zhao,* “An Amphiphilic Molecular Basket Sensitive to Both Solvent Changes and UV Irradiation,” J. Org. Chem. 2006, 71, 9491–9494. http://dx.doi.org/10.1021/jo061672w


20. Yan Zhao* and Zhenqi Zhong, “Detection of Hg2+ in Aqueous Solutions with a Foldamer-Based Fluorescent Sensor Modulated by Surfactant Micelles,” Org. Lett. 2006, 8, 4715–4717. http://dx.doi.org/10.1021/ol061735x

2005_OL_Hg micelle

19. Eui-Hyun Ryu, Jie Yan, Zhenqi Zhong, and Yan Zhao,* “Solvent-Induced Amphiphilic Molecular Baskets: Unimolecular Reversed Micelles with Different Size, Shape, and Flexibility,” J. Org. Chem. 2006, 71, 7205–7213. http://dx.doi.org/10.1021/jo0607663

2006_JOC_amphi baskets

18. Yan Zhao* and Zhenqi Zhong, “Tuning the Sensitivity of a Foldamer-Based Mercury Sensor by Its Folding Energy,” J. Am. Chem. Soc. 2006, 128, 9988–9989. http://dx.doi.org/10.1021/ja062001i

2006_JACS_Hg foldamer

17. Eui-Hyun Ryu, Arkady Ellern, and Yan Zhao,* “High Guest Inclusion by 3-beta-Amino-7-alpha,12- alpha -Dihydroxycholan-24-oic Acid Made Possible by Charge-Assisted Hydrogen Bonds,” Tetrahedron 2006, 62, 6808–6813. http://dx.doi.org/10.1016/j.tet.2006.04.094



17. Yan Zhao* and Zhenqi Zhong, “Oligomeric Cholates: Amphiphilic Foldamers with Nanometer-Sized Hydrophilic Cavities,” J. Am. Chem. Soc. 2005, 127, 17894–17901. http://dx.doi.org/10.1021/ja056151p


16. Yan Zhao* and Eui-Hyun Ryu, “Solvent-Tunable Binding of Hydrophilic and Hydrophobic Guests by Amphiphilic Molecular Baskets,” J. Org. Chem. 2005, 70, 7585–7591. http://dx.doi.org/10.1021/jo051127f

2005_JOC_binding basket

15. Zhenqi Zhong, Jie Yan, and Yan Zhao,* “Cholic Acid-Derived Facial Amphiphiles with Different Ionic Characteristics,” Langmuir 2005, 21, 6235–6239. http://dx.doi.org/10.1021/la050621b


14. Eui-Hyun Ryu and Yan Zhao,* “Efficient Synthesis of Water-Soluble Calixarenes Using Click Chemistry,” Org. Lett. 2005, 7, 1035–1037. http://dx.doi.org/10.1021/ol047468h

2005_OL_clicked Calix


13. Eui-Hyun Ryu and Yan Zhao, * “Environmentally Responsive Molecular Baskets: Unimolecular Mimics of Both Micelles and Reversed Micelles,” Org. Lett. 2004, 6, 3187–3189. http://dx.doi.org/10.1021/ol048679p



12. Laura G. Schultz, Yan Zhao, and Steven C. Zimmerman,* “Synthesis of Cored Dendrimers with Internal Cross-Links,” Angew. Chem. Int. Ed. 2001, 40, 1962–1966.

11. Joseph B. Lambert,* Yan Zhao, and S. Mark Zhang, “Preparation of the Tricoordinate Silyl Cation,” J. Phys. Org. Chem. 2001, 14, 370–379. http://dx.doi.org/10.1002/poc.377

10. Joseph B. Lambert,* Yan Zhao, Hongwei Wu, Winston C. Tse, and Barbara Kuhlmann, “The Allyl Leaving Group Approach to Tricoordinate Silyl, Germyl, and Stannyl Cations,” J. Am. Chem. Soc. 1999, 121, 5001–5008. http://dx.doi.org/10.1021/ja990389u

9. Joseph B. Lambert,* Yan Zhao, and Hongwei Wu, “Beta-Silyl and Beta-Germyl Carbocations Stable at Room Temperature,” J. Org. Chem. 1999, 64, 2729–2736. http://dx.doi.org/10.1021/jo982146a

8. Joseph B. Lambert,* Yan Zhao, Robert W. Emblidge, Lourdes A. Salvador, Xiaoyang Liu, Jeung-Ho So, and Erik C. Chelius, “The Beta Effect of Silicon and Related Manifestations of Sigma Conjugation,” Acc. Chem. Res. 1999, 32, 183–190. http://dx.doi.org/10.1021/ar970296m

7. Joseph B. Lambert,* Charlotte L. Stern, Yan Zhao, Winston Tse, Catherine E. Shawl, Kirk T. Lentz, and Lidia Kania, “Torsional Distortions in Trimesitylsilanes and Trimesitylgermanes,” J. Organomet. Chem. 1998, 568, 21–31. 

6. Thomas Müller,* Yan Zhao, and Joseph B. Lambert, “Computational Evidence for a Free Silylium Ion,” Organometallics 1998, 17, 278–280. http://dx.doi.org/10.1021/om971003w

5. Joseph B. Lambert,* Yan Zhao, and Charlotte L. Stern, “Two-dimensional Lattice of Superboats Composed of Silicon-centered Tetrahedra,” J. Phys. Org. Chem. 1997, 10, 229–232.

4. Joseph B. Lambert* and Yan Zhao, “The Trimesitylsilylium Cation,” Angew. Chem. Int. Ed. 1997, 36, 400–401 (highlighted in C&E News, January 6, 1997, page 7–8; Science 1997, 275, 39-40; Chemtracts 1997, 10, 841-843; Angew. Chem. Int. Ed. Engl. 1997, 36, 1277–1280). http://dx.doi.org/10.1002/anie.199704001

3. Joseph B. Lambert* and Yan Zhao, “A Stable Beta-Silyl Carbocation,” J. Am. Chem. Soc. 1996, 118, 7867–7868 (see also C&E News, August 26, 1996, page 31). http://dx.doi.org/10.1021/ja9613670

2. Joseph B. Lambert* and Yan Zhao, “Beta Effect of Phosphorus Functionalities,” J. Am. Chem. Soc. 1996, 118, 3156–3167. http://dx.doi.org/10.1021/ja9537181

1. Joseph B. Lambert,* Robert W. Emblidge, and Yan Zhao, “Participation of the Beta Phosponate Group in Carbocation Formation,” J. Org. Chem. 1994, 59, 5397–5403. http://dx.doi.org/10.1021/jo00097a050