Chemical Biology

Professor Interests
Robbyn Anand Bioanalytical; microfluidics; electrochemistry; separations.
George Kraus Their approach to total synthesis involves first the creation of generally-useful methodology for natural product subunits (such as quinones or lactones) which are common to a variety of natural products. This methodology is then applied to those compounds for which it is most appropriate. The development of methods for quinone synthesis has led to highly efficient and regioselective syntheses of pyranonaphthoquinones.
Young Jin Lee Bioanalytical chemistry is the first step toward understanding in chemical biology. The Lee group is working on bioanalytical chemistry to solve biological problems. Mass spectrometry imaging: cellular and sub cellular level high resolution molecular imaging technique for unprecedented understanding of plant metabolic biology. Structural mass spectrometry: cross-linking and oxidation labeling mass spectrometry technique for 3D protein structure analysis.
Jacob Petrich Recently they have become involved in developing sensitive devices for the detection of environmental contaminants, in particular for use in food safety and health applications. They have most recently developed, patented, and licensed a technology based on fluorescence detection for use in the real-time identification of contaminated meat products.
Davit Potoyan Our group develops and applies theoretical concepts and computational tools for solving wide variety of problems in cellular and molecular biophysics. Central theme of our research is understanding how collective interactions in biomolecules are harnessed for system level regulation in cells. Specifically we are looking at genetic networks of higher organisms in order to uncover mechanisms by which cells carry out complex information processing and biological computations enabling survival and adaptation in dynamic and unpredictable environments. The problems we study often require a multi-scale computational approach where we employ some blend of hybrid stochastic simulations, brownian dynamics and molecular dynamics techniques for investigating biological networks and individual biomolecular components.
Igor Slowing The Slowing group designs multifunctional nanostructured materials to build smart hybrid organic-inorganic devices. We synthesize nanoparticles with precise control of morphology and surface properties, and incorporate organic and inorganic groups at specific domains of the particles.
Emily Smith Developing fluorescence and vibrational imaging techniques that can be used to study biomolecular processes in cells and tissue. The clustering of cell membrane proteins, the interaction of cell membrane proteins with extracellular and cytosolic proteins, and the post-translational modification of proteins are studied. The aim of this work is to further the understanding of molecular interactions in vivo, to provide insight into how cellular processes are altered in certain disease states, and to develop methods for screening potential therapeutic compounds.
Levi Stanley Over the past decades, the discovery of new catalyst systems has transformed the way that organic chemists approach the synthesis of medicinally important compounds, natural products, and organic materials. Although catalysis is now a staple of modern synthetic organic chemistry, the demand for new catalysts, particularly transition metal catalysts that lead to greener, more efficient and versatile synthetic processes, remains strong.
Brett VanVeller Our research program aims to develop tools and biomimetic materials to interrogate, understand, and manipulate the interactions that occur between biological building blocks. Synthetic chemistry and the develpoment of new methods underpin all aspects of our research, and we apply the principles of chemistry towards the precise molecular-level design and engineering of these systems.
Vincenzo Venditti In our lab, the structure, dynamics and interactions of enzymatic proteins are studied using a broad range of biophysical techniques. Our experimental approach involves state-of-the-art methods in biomolecular NMR, computer simulations, enzymology, and protein chemistry. Our research is primarily focused on determining how enzymatic activity and regulation are coupled to structural and dynamical features of an enzyme. Moreover, we look forward to applying the information gathered from these studies to the development of new inhibitors and bacterial systems.
Theresa Windus Modern theoretical and computational chemical science is a confluence of mathematics, physics, computer science, chemistry and sometimes biology. It is at the interface between these disciplines where many of the most exciting new developments in the field are being made. The scientific questions being asked demand much more from the theories, the computational algorithms and the scientist's chemical intuition than in previous years.
Yan Zhao The biological world has unparalleled abilities to control structures, functions, reactions, and energy transfer with great efficiency and accuracy. They are interested in biomimetic chemistry to "abstract good design from nature." One of their main research goals is to design molecules that functionally mimic certain biological systems, and in turn to prepare molecules, polymers, and materials that have useful and superior properties.