Controlling Biology with Constrained Peptides

Friday, September 27, 2019 - 1:10pm
Event Type: 

Joshua KritzerJoshua Kritzer

Department of Chemistry, Tufts University


The Kritzer Lab uses innovative molecules to block disease-associated proteins, often in ways

traditional "drug-like" molecules cannot. Several projects are exploring new ways to

synthesize and screen constrained peptides, which are molecules with unique abilities to bind

protein surfaces and block protein-protein interactions. Discovering new bioactive molecules

is only the first step. however. In several other projects, we are exploring new methods for

measuring cell penetration, which is the most difficult roadblock for many emerging

therapeutics including peptide therapeutics, protein therapeutics, RNA therapeutics, and gene