Controlling Biology with Constrained Peptides

Event
Friday, September 27, 2019 - 1:10pm
Event Type: 

Joshua KritzerJoshua Kritzer

Department of Chemistry, Tufts University

(VanVeller)

The Kritzer Lab uses innovative molecules to block disease-associated proteins, often in ways
traditional "drug-like" molecules cannot. Several projects are exploring new ways to
synthesize and screen constrained peptides, which are molecules with unique abilities to bind
protein surfaces and block protein-protein interactions. Discovering new bioactive molecules
is only the first step. however. In several other projects, we are exploring new methods for
measuring cell penetration, which is the most difficult roadblock for many emerging
therapeutics including peptide therapeutics, protein therapeutics, RNA therapeutics, and gene
editing.