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UID:20240419T202000-883-www.chem.iastate.edu
DTSTART:20240419T202000Z
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LOCATION:1352 Gilman
SUMMARY:Seminar: Boone M. Prentice
CLASS:PUBLIC
DESCRIPTION:Boone M. Prentice\, Ph.D.Assistant ProfessorUniversity of Flori
 daHosted by: Young-Jin LeeAbstractImaging with high chemical and spatial r
 esolutions using mass spectrometryImaging mass spectrometry is a powerful 
 analytical technique for analyzing the spatial lipidome. This technology e
 nables the visualization of molecular pathology directly in tissues by com
 bining the specificity of mass spectrometry with the spatial fidelity of m
 icroscopic imaging. This label-free methodology has proven exceptionally u
 seful in research areas such as cancer diagnosis\, diabetes\, and infectio
 us disease. However\, state-of-the-art experiments stress the limits of cu
 rrent analytical technologies\, necessitating improvements in molecular sp
 ecificity and sensitivity in order to answer increasingly complicated biol
 ogical and clinical hypotheses. Especially when studying lipids\, many iso
 baric (i.e.\, same nominal mass) and isomeric (i.e.\, same exact mass) com
 pounds exist that complicate spectral analysis\, with each structure havin
 g a potentially unique cellular function. The Prentice Lab develops instru
 mentation and novel gas-phase reactions to provide unparalleled levels of 
 chemical resolution. These gas-phase transformations are fast\, efficient\
 , and specific\, making them ideally suited for implementation into imagin
 g mass spectrometry workflows. For example\, these workflows have enabled 
 the identification of multiple sn-positional phosphatidylcholine isomers\,
  the separation of isobaric phosphatidylserines and sulfatides\, and the i
 dentification of fatty acid double bond isomers using a variety of charge 
 transfer and covalent ion/ion reactions as well as ion/electron and ion/ph
 oton reactions. Working with biologists and clinicians\, we then leverage 
 these novel imaging technologies to understand the molecular events associ
 ated with important problems in human health\, including infectious diseas
 e\, diabetes\, and neurodegenerative diseases.BioBoone Prentice is Assista
 nt Professor in the Department of Chemistry at the University of Florida. 
 He received his B.S. in Chemistry from Longwood University (Farmville\, VA
 )\, and completed his Ph.D. in Chemistry at Purdue University (West Lafaye
 tte\, IN) under the mentorship of Prof. Scott McLuckey studying gas-phase 
 ion/ion reactions and ion trap instrumentation. He then completed his post
 doctoral work in the Department of Biochemistry at Vanderbilt University (
 Nashville\, TN) as an NIH NRSA fellow under the guidance of Prof. Richard 
 Caprioli before joining the faculty at UF in 2018. He was awarded an NIH F
 ocused Technology Research and Development R01 grant in 2020 and a JDRF In
 novation Award in 2023 to support his research developing gas-phase reacti
 ons and imaging mass spectrometry technologies to study the molecular path
 ology of diabetes\, infectious disease\, neurodegeneration\, and neurophar
 macology. He was also awarded the 2022 Young Investigator Award from Eli L
 illy and Company\, which is an unsolicited award given annually by Eli Lil
 ly’s Analytical Chemistry Academic Contacts Committee to recognize a “
 rising star” in analytical chemistry\, and was highlighted as a 2023 Eme
 rging Investigator by the Journal of the American Society for Mass Spectro
 metry and as a 2023 Young Investigator in (Bio-)Analytical Chemistry by An
 alytical and Bioanalytical Chemistry.\n\nMore information at: https://www.
 chem.iastate.edu/event/2024/seminar-boone-m-prentice
DTSTAMP:20260910T131947Z
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