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Selected Publications

1. E. W. Yu, G. McDermott, H. I. Zgurskaya, H. Nikaido, and D. E. Koshland, Jr., "Structural Basis of Multiple Drug-Binding Capacity of the AcrB Multidrug Efflux Pump", Science, 2003, 300, 976-980.
2. E. W. Yu, J. R. Aires, and H. Nikaido, "AcrB Multidrug Efflux Pump of Escherichia coli: A composite substrate-binding cavity of an exceptional flexibility generates its extremely wide substrate specificity", J. Bacteriol., 2003, 185, 5657-5664.
3. E. W. Yu, J. R. Aires, G. McDermott, and H. Nikaido, "A Periplasmic Drug-Binding Site of the AcrB Multidrug Efflux Pump: A Crystallographic and Site-Directed Mutagenesis Study", J. Bacteriol., 2005, 187, 6804-6815.
4. W. C. Lu, C. Z. Wang, E. W. Yu, and K. M. Ho, "Dynamics of the Trimeric AcrB Transporter Protein Inferred from a B-factor Analysis of the Crystal Structure", Proteins, 2006, 62, 152-158.
5. C.-C. Su, M. Li, R. Gu, Y. Takatsuka, G. McDermott, H. Nikaido, and E. W. Yu, "Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway", J. Bacteriol., 2006, 188, 7290-7296.
6. M. Li, X. Qiu, C.-C. Su, F. Long, R. Gu, G. McDermott, and E. W. Yu, "Cloning, Expression, Purification, Crystallization and Preliminary X-ray Diffraction Analysis of the Regulator AcrR from Escherichia Coli", Acta Cryst., 2006, F62, 1150-1152.
7. C.-C. Su, F. Shi, R. Gu, M. Li, G. McDermott, E. W. Yu, and Q. Zhang, "Preliminary structural studies of the transcriptional regulator CmeR from Campylobacter jejuni", Acta Cryst., 2007, F63, 34-36.
8. C.-C. Su, D. J. Rutherford, and E. W. Yu, "Characterization of the multidrug efflux regulator AcrR from Escherichia coli", Biochem. Biophys. Res. Comm., 2007, 361, 85-90.
9. R. Gu, C.-C. Su, F. Shi, M. Li, G. McDermott, Q. Zhang, and E. W. Yu, "Crystal structure of the transcriptional regulator CmeR from Campylobacter jejuni", J. Mol. Biol., 2007, 372, 583-593.
10. C.-C. Su, and E. W. Yu, "Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay", FEBS Lett., 2007, 581, 4872-4976.
11. M. Li, R. Gu, C.-C. Su, M. D. Routh, K. C. Harris, E. S. Jewell, G. McDermott, and E. W. Yu, "Crystal structure of the transcriptional regulator AcrR from Escherichia coli", J. Mol. Biol., 2007, 374, 591-603.
12. C.-C. Su, F. Long, G. McDermott, W. M. Shafer, and E. W. Yu, "Crystallization and preliminary X-ray diffraction analysis of the multidrug efflux transporter NorM from Neisseria gonorrhoeae", Acta Cryst., 2008, F64, 289-292.
13. R. Gu, M. Li, C.-C. Su, F. Long, M. D. Routh, F. Yang, G. McDermott, and E. W. Yu, "Conformational change of the AcrR regulator reveals a possible mechanism of induction", Acta Cryst., 2008, F64, 584-588.
14. F. Long, C. Rouquette-Loughlin, W. M. Shafer, and E. W. Yu, "Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli", Antimicrob. Agents Chemother., 2008, 52, 3052-3060.
15. M. D. Routh, C.-C. Su, Q. Zhang, and E. W. Yu, "Structures of CmeR and AcrR: Insight into the mechanisms of transcriptional repression and multi-drug recognition in the TetR family of regulators", Biochim. Biophys. Acta, 2009, 1794, 844-851.
16. C.-C. Su, F. Yang, F. Long, D. Reyon, M. D. Routh, D. W. Kuo, A. K. Mokhtari, J. D. Van Ornam, K. L. Rabe, J. A. Hoy, Y. J. Lee, K. R. Rajashankar, and E. W. Yu, "Crystal structure of the membrane fusion protein CusB from Escherichia coli", J. Mol. Biol., 2009, 393, 342-355.
17. F. Long, C.-C. Su, M. T. Zimmermann, S. E. Boyken, K. R. Rajashankar, R. L. Jernigan, and E. W. Yu, "Crystal structures of the CusA heavy-metal efflux pump suggest methionine-mediated metal transport", Nature, 2010, (In press).