Edward Yu


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Selected Publications

Delmar, J. A. and E. W. Yu. 2016. The AbgT family: A novel class of antimetabolite transporters. Prot. Sci. 25:322-337. PMID: 26443496

Kumar, N., A. Radhakrishnan, C.-C. Su, K. Osteryoung and E. W. Yu. 2016. Crystal structure of a conserved domain in the intermembrane space region of the plastid division protein ARC6. Prot. Sci. 25:523-529. PMID: 26452626

Zheng, F., A. P. Robertson, M. Abongwa, E. W. Yu, and R. J. Martin. 2016. The ascaris suum nicotinic receptor, ACR-16, as a drug target: four noand vel negative allosteric modulators from virtual screening. Int. J. Parasit. 6:60-73. PMID: 27054065

Delmar JA, Chou TH, Wright CC, Licon MH, Doh JK, Radhakrishnan A, Kumar N, Lei HT, Bolla JR, Rajashankar KR, Su CC, Purdy GE, Yu EW. Structural Basis for the Regulation of the MmpL Transporters of Mycobacterium tuberculosis. 2015 Sep 22. J Biol Chem. pii: jbc.M115.683797. PMID: 26362239

Chou TH, Delmar JA, Wright CC, Kumar N, Radhakrishnan A, Doh JK, Licon MH, Bolla JR, Lei HT, Rajashankar KR, Su CC, Purdy GE, Yu EW. Crystal structure of the Mycobacterium tuberculosis transcriptional regulator Rv0302. 2015 Sep 12. Protein Sci. doi: 10.1002/pro.2802. PMID: 26362239

Delmar, J. A., *C.-C. Su and E. W. Yu. 2015. CusC heavy metal efflux channel of Escherichia coli. “Encyclopedia of Inorganic and Bioinorganic Chemistry”. doi:10.1002/9781119951438.eibc2324.

Delmar JA, Su CC, Yu EW. Heavy metal transport by the CusCFBA efflux system. 2015 Aug 10. Protein Sci. doi: 10.1002/pro.2764. PMID: 26258953

Delmar JA, Bolla JR, Su CC, Yu EW. Crystallization of membrane proteins by vapor diffusion. Methods Enzymol. Epub 2015 Mar 24. doi: 10.1016/bs.mie.2014.12.018. PMID: 25950974

Bolla JR, Su CC, Delmar JA, Radhakrishnan A, Kumar N, Chou TH, Long F, Rajashankar KR, Yu EW. Crystal structure of the Alcanivorax borkumensis YdaH transporter reveals an unusual topology. Nat Commun. 2015 Apr 20. doi: 10.1038/ncomms7874. PMID: 25892120

Su CC, Bolla JR, Kumar N, Radhakrishnan A, Long F, Delmar JA, Chou TH, Rajashankar KR, Shafer WM, Yu EW. Structure and function of Neisseria gonorrhoeae MtrF illuminates a class of antimetabolite efflux pumps. Cell Rep. 2015 Mar 26. doi: 10.1016/j.celrep.2015.03.003. PMID: 25818299

Bolla JR, Su CC, Do SV, Radhakrishnan A, Kumar N, Long F, Chou TH, Delmar JA, Lei HT, Rajashankar KR, Shafer WM, Yu EW.Crystal structure of the Neisseria gonorrhoeae MtrD inner membrane multidrug efflux pump. PLoS One. 2014 Jun 5 doi:10.1371/journal.pone.0097903.PMID: 24901477

Lei HT, Chou TH, Su CC, Bolla JR, Kumar N, Radhakrishnan A, Long F, Delmar JA, Do SV, Rajashankar KR, Shafer WM, Yu EW.Crystal structure of the open state of the Neisseria gonorrhoeae MtrE outer membrane channel. PLoS One. 2014 Jun 5 doi:10.1371/journal.pone.0097475. PMID: 24901251

Su CC, Radhakrishnan A, Kumar N, Long F, Bolla JR, Lei HT, Delmar JA, Do SV, Chou TH, Rajashankar KR, Zhang Q, Yu EW. Crystal structure of the Campylobacter jejuni CmeC outer membrane channel. Protein Sci. 2014 July 6 doi: 10.1002/pro.2478. PMID: 24753291

Radhakrishnan A, Kumar N, Wright CC, Chou TH, Tringides ML, Bolla JR, Lei HT, Rajashankar KR, Su CC, Purdy GE, Yu EW. Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis. J Biol Chem. 2014 Jun 6 doi: 10.1074/jbc.M113.538959. PMID: 24737322

Delmar JA, Su CC, Yu EW. Bacterial Multidrug Efflux Transporters. 2014. Annu. Rev. Biophys. In press. doi: 10.1146/annurev-biophys-051013-022855

Kumar N, Radhakrishnan A, Wright CC, Chou TH, Lei HT, Bolla JR, Tringides ML, Rajashankar KR, Su CC, Purdy GE, Yu EW. Crystal Structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis. Protein Sci. 2014 Jan 14. doi: 10.1002/pro.2424. PMID: 24424575

Lei HT, Bolla JR, Bishop NR, Su CC, Yu EW. Crystal structures of CusC review conformational changes accompanying folding and transmembrane channel formation. J Mol Biol. 2014 Jan 23;426(2):403-11. doi: 10.1016/j.jmb.2013.09.042. Epub 2013 Oct 4. PMID: 24099674

Delmar JA, Su CC, Yu EW. Structural mechanisms of heavy-metal extrusion by the Cus efflux system. Biometals. 2013 Aug;26(4):593-607. doi: 10.1007/s10534-013-9628-0. Epub 2013 May 9. PubMed PMID: 23657864

Do SV, Su CC, Long F, Lei HT, Bolla JR, and Yu EW. Structure, Mechanism and Assembly of the Tripartite CusCBA Heavy Metal Efflux Complex. Microbial Efflux Pumps: Current Research. Eds. Yu EW, Zhang Q, Brown MH. Norfolk, UK. 2013. 50-77. Print. (Cover)

Shen Z, Su CC, Yu EW, and Zhang Q. 2013. Multidrug efflux transporters in Campylobacter. Microbial Efflux Pumps: Current Research. Eds. Yu EW, Zhang Q, Brown MH. Norfolk, UK. 2013. 223-235. Print.

Bolla JR, Do SV, Long F, Dai L, Su CC, Lei HT, Chen X, Gerkey JE, Murphy DC, Rajashankar KR, Zhang Q, Yu EW. Structural and functional analysis of the transcriptional regulator Rv3066 of Mycobacterium tuberculosis. Nucleic Acids Res. 2012 Oct;40(18):9340-55. doi: 10.1093/nar/gks677. Epub 2012 Jul 19. PubMed PMID:22821564.

Su CC, Long F, Lei HT, Bolla JR, Do SV, Rajashankar KR, Yu EW. Charged Amino Acids (R83, E567, D617, E625, R669, and K678) of CusA Are Required for Metal Ion Transport in the Cus Efflux System. J Mol Biol. 2012 Sep 21;422(3):429-41. Epub 2012 Jun 6. PubMed PMID:22683351.

Bolla JR, Su CC, Yu EW. Biomolecular membrane protein crystallization. Philos Mag (Abingdon). 2012 Jul 1;92(19-21):2648-2661. PMID: 23869195

Long F, Su CC, Lei HT, Bolla JR, Do SV, Yu EW. Structure and mechanism of the tripartite CusCBA heavy-metal efflux complex. Philos Trans R Soc Lond B Biol Sci. 2012 Apr 19;367(1592):1047-58. Review. PubMed PMID:22411977; PubMed Central PMCID: PMC3297434.

Su CC, Long F, Yu EW. CusBA heavy-metal complex of Escherichia coli. Encyclopedia of Inorganic and Bioinorganic Chemistry. 2012. doi:10.1002/9781119951438.eibc2054 .

Routh MD, Zalucki Y, Su CC, Zhang Q, Shafer WM, Yu EW. Efflux pumps of the resistance-nodulation-division family: a perspective of their structure, function, and regulation in gram-negative bacteria. Adv Enzymol Relat Areas Mol Biol. 2011;77:109-46. Review. PubMed PMID:21692368.

Su CC, Long F, Zimmermann MT, Rajashankar KR, Jernigan RL, Yu EW. Crystal structure of the CusBA heavy-metal efflux complex of Escherichia coli. Nature. 2011 Feb 24;470(7335):558-62. PubMed PMID:21350490; PubMed Central PMCID: PMC3078058.

Lei HT, Shen Z, Surana P, Routh MD, Su CC, Zhang Q, Yu EW. Crystal structures of CmeR-bile acid complexes from Campylobacter jejuni. Protein Sci. 2011 Apr;20(4):712-23. doi: 10.1002/pro.602. PubMed PMID:21328631; PubMed Central PMCID: PMC3081549.

Su CC, Long F, Yu EW. The Cus efflux system removes toxic ions via a methionine shuttle. Protein Sci. 2011 Jan;20(1):6-18. Review. PubMed PMID:20981744; PubMed Central PMCID: PMC3047057.

Long F, Su CC, Zimmermann MT, Boyken SE, Rajashankar KR, Jernigan RL, Yu EW. Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport. Nature. 2010 Sep 23;467(7314):484-8. PubMed PMID:20865003; PubMed Central PMCID: PMC2946090.

Su CC, Yang F, Long F, Reyon D, Routh MD, Kuo DW, Mokhtari AK, Van Ornam JD, Rabe KL, Hoy JA, Lee YJ, Rajashankar KR, Yu EW. Crystal structure of the membrane fusion protein CusB from Escherichia coli. J Mol Biol. 2009 Oct 23;393(2):342-55. Epub 2009 Aug 18. PubMed PMID:19695261; PubMed Central PMCID: PMC2792208.

Routh, M. D., C.-C. Su, Q. Zhang, and E. W. Yu. 2009. Structures of AcrR and CmeR: Insights into the mechanisms of transcriptional repression and multi-drug recognition in the TetR family of regulators. Biochim. Biophys. Acta 2009 May;1794(5):844-51. doi: 10.1016/j.bbapap.2008.12.001. Epub 2008 Dec 14. PubMed PMID:19130905

Routh MD, Su CC, Zhang Q, Yu EW. Structures of AcrR and CmeR: insight into the mechanisms of transcriptional repression and multi-drug recognition in the TetR family of regulators. Biochim Biophys Acta. 2009 May;1794(5):844-51. Epub 2008 Dec 14. Review. PubMed PMID:19130905; PubMed Central PMCID: PMC2729549.

Gu R, Li M, Su CC, Long F, Routh MD, Yang F, McDermott G, Yu EW. Conformational change of the AcrR regulator reveals a possible mechanism of induction. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 1;64(Pt 7):584-8. Epub 2008 Jun 11. PubMed PMID:18607081; PubMed Central PMCID: PMC2443975.

Long F, Rouquette-Loughlin C, Shafer WM, Yu EW. Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Antimicrob Agents Chemother. 2008 Sep;52(9):3052-60. Epub 2008 Jun 30. PubMed PMID:18591276; PubMed Central PMCID: PMC2533508.

Su CC, Long F, McDermott G, Shafer WM, Yu EW. Crystallization and preliminary X-ray diffraction analysis of the multidrug efflux transporter NorM from Neisseria gonorrhoeae. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Apr 1;64(Pt 4):289-92. Epub 2008 Mar 21. PubMed PMID:18391429; PubMed Central PMCID: PMC2374251.

Li M, Gu R, Su CC, Routh MD, Harris KC, Jewell ES, McDermott G, Yu EW. Crystal structure of the transcriptional regulator AcrR from Escherichia coli. J Mol Biol. 2007 Nov 30;374(3):591-603. Epub 2007 Sep 29. PubMed PMID:17950313; PubMed Central PMCID: PMC2254304.

Su CC, Yu EW. Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay. FEBS Lett. 2007 Oct 16;581(25):4972-6. Epub 2007 Sep 25. Erratum in: FEBS Lett. 2007 Nov 27;581(28):5548. PubMed PMID:17910961; PubMed Central PMCID: PMC2254335.

Gu R, Su CC, Shi F, Li M, McDermott G, Zhang Q, Yu EW. Crystal structure of the transcriptional regulator CmeR from Campylobacter jejuni. J Mol Biol. 2007 Sep 21;372(3):583-93. Epub 2007 Jul 3. PubMed PMID:17686491; PubMed Central PMCID: PMC2104645.

Su CC, Rutherford DJ, Yu EW. Characterization of the multidrug efflux regulator AcrR from Escherichia coli. Biochem Biophys Res Commun. 2007 Sep 14;361(1):85-90. Epub 2007 Jul 17. PubMed PMID:17644067; PubMed Central PMCID: PMC2104644.

Su CC, Shi F, Gu R, Li M, McDermott G, Yu EW, Zhang Q. Preliminary structural studies of the transcriptional regulator CmeR from Campylobacter jejuni. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jan 1;63(Pt 1):34-6. Epub 2006 Dec 16. PubMed PMID:17183170; PubMed Central PMCID: PMC2330109.

Li M, Qiu X, Su CC, Long F, Gu R, McDermott G, Yu EW. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the regulator AcrR from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt 11):1150-2. Epub 2006 Oct 20. PubMed PMID:17077502; PubMed Central PMCID: PMC2225224.

Su CC, Li M, Gu R, Takatsuka Y, McDermott G, Nikaido H, Yu EW. Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway. J Bacteriol. 2006 Oct;188(20):7290-6. PubMed PMID:17015668; PubMed Central PMCID: PMC1636240.

Lu WC, Wang CZ, Yu EW, Ho KM. Dynamics of the trimeric AcrB transporter protein inferred from a B-factor analysis of the crystal structure. Proteins. 2006 Jan 1;62(1):152-8. PubMed PMID:16288462; PubMed Central PMCID: PMC2705243.

Yu EW, Aires JR, McDermott G, Nikaido H. A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study. J Bacteriol. 2005 Oct;187(19):6804-15. PubMed PMID:16166543; PubMed Central PMCID: PMC1251581.

Yu EW, Aires JR, Nikaido H. AcrB multidrug efflux pump of Escherichia coli: composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity. J Bacteriol. 2003 Oct;185(19):5657-64. Review. PubMed PMID:13129936; PubMed Central PMCID: PMC193975.

Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland DE Jr. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science. 2003 May 9;300(5621):976-80. PubMed PMID:12738864.

 

Books Edited

Microbial Efflux Pumps: Current Research. Horizon Scientific Press Ltd., UK.
http://www.horizonpress.com/efflux-pumps

Cover Pages

Cell Reports


2014 Cell Reports

Protein Science

 
2011 Protein Science

2014 Protein Science

2016 Protein Science